Vitamin K and bone

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Vitamin K and metabolic bone disease.

Originally, vitamin K was defined as a factor concerned with haemostasis, deficiency resulting in a haemorrhagic disease. After the initial discovery of phylloquinone in 1929, various compounds were described which all had “vitamin K activity,” that is, the ability to restore normal haemostasis in vitamin K deficient animals. It turned out that “vitamin K” is a group name for several related co...

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Vitamin K, bone turnover, and bone mass in girls.

BACKGROUND Vitamin K has been suggested to have a role in bone metabolism, and low vitamin K intake has been related to low bone density and increased risk of osteoporotic fracture. OBJECTIVE The objective of this study was to determine whether phylloquinone (vitamin K(1)) intake and biochemical indicators of vitamin K status are related to bone mineral content (BMC) and markers of bone forma...

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Action of vitamin K on bone health

Objetives: Nowadays it is recognised that vitamin K plays an important role in bone health. It is necessary for the gamma-carboxylation of osteocalcin (the most important non-collagen protein in the bone), making the osteocalcin function. There are two important forms of vitamin K (vitamin K1 and vitamin K2), which come from different sources and have different biological activity. Epidemiologi...

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Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats.

The difference between vitamin K metabolism in the liver and that in the bone of vitamin K-deficient rats was examined. After 17 d administration of vitamin K-deficient food, vitamin K in the liver was almost depleted, and prothrombin time (PT) was prolonged. Serum total osteocalcin level was slightly decreased by vitamin K deficiency, whereas serum undercarboxylated osteocalcin level did not c...

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The Role of Vitamin K in Bone Remodeling and Osteoporosis

Vitamin K is an essential fat soluble vitamin involved in the regulation of normal coagulation. However, growing evidence highlights that this molecule appears to be also implicated in the regulation of other important biological functions such as bone mineralization, calcium homeostasis, apoptosis, cell growth and signal transduction. In particular, many studies have focused their attention on...

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ژورنال

عنوان ژورنال: Clinical Cases in Mineral and Bone Metabolism

سال: 2017

ISSN: 1971-3266

DOI: 10.11138/ccmbm/2017.14.1.200